Scientific Overview

Scientific Overview

Achelios_Scientific Overview

Achelios Therapeutics, a pioneering Chapel Hill-based drug development company, creates advanced, innovative drug candidates with the potential to satisfy unmet medical needs. We focus on topically delivered medications (applied to the skin or mucous membranes) for the safe and effective treatment of ailments such as pain and inflammation.

Some hydrophobic chemicals, such as steroid hormones, can be absorbed into the body after dermal application in the form of a cream, foam, gel, ointment, or lotion. Transdermal patches have become a popular means of administering some drugs for birth control, hormone replacement therapy, and prevention of motion sickness. Other examples of topical therapies are the application of antibiotics, antifungals, anti-inflammatories, and antiviral medications.

TOPOFEN™ is a clinical stage product that pairs Achelios’ powerful transdermal drug delivery technology, TOPOGEL™, with the well-established non-steroidal anti-inflammatory molecule, ketoprofen. TOPOFEN™ is formulated as a 5% ketoprofen gel for the indication of acute migraine; a similar formula would likely be used for migraine prophylaxis and TMJ. additional indications of osteoarthritis and sprains and strains, will be targeted with alternative formulations

The clinical results achieved by Achelios Therapeutics have been significant to date and demonstrate that our drug formulations offer superior skin permeation compared to many commercial brands; the Achelios formulation greatly enhances the permeation of selective pain and anti-inflammatory agents across human skin between 4 and 9 times greater than that of leading commercial brands.