Other Indications and Potential Markets

Indications and Potential Markets

Other Indications and Potential Markets – Osteoarthritis, Sprains and Strains, and TMJ

Achelios Indications Potential MarketsOsteoarthritis (OA), the most common form of arthritis, is a condition characterized by the loss of articular cartilage within the synovial joints, associated with hypertrophy of the bone and thickening of the capsule. OA can be subclassified as either primary (not related to prior conditions affecting the joint) or secondary (the joint had a previous condition). While studies have shown there may be some hereditary contribution to OA, there is not a clear single factor that causes primary OA. Common causes of secondary OA include fractures, congenital disorders, diabetes, obesity, and metabolic disorders. The main symptom of OA is pain, which can cause stiffness and the loss of mobility in the associated areas. OA is most common in the hands, neck, spine, and other joints that bear significant weight such as hips and knees. OA has multiple risk factors, which can broadly be divided into demographic, clinical, behavioral, biomechanical, and genetic. The prevalence of OA increases with age and is higher among women.

The seven major markets show a prevalence of over 100 million knee, hip, and hand OA cases each year in patients aged 45 years and older. This number is expected to increase by more than 20% between 2012 and 2024, with an increase of about 50% in the US alone during the same time period. This is likely due to higher levels of obesity and an aging population.

Sprains and strains are some of the most common injuries in athletes and individuals who lead active lifestyles. A sprain is a stretch and/or tear of a ligament, whereas a strain refers to an injury of a tendon or muscle. Sprains and strains are primarily treated with a combination of rest, oral or topical painkillers, and physical therapy.

Due to the ill-defined nature of the sprains and strains indication, it can be difficult to arrive at the total size of such a potential market. However, our estimates place the overall market size in the US at about 4.5% of the overall population, or approximately 14.5 million individuals. Similarly, our estimates for Europe see a 4.5% incidence rate of sprains and strains resulting in approximately 18 million potential cases in the main European countries.

Temporomandibular joint (TMJ) disorders are technically a form of arthritis and estimated to impact as many as 10 million individuals each year in the US. The most common symptom that presents in cases of TMJ disorders is pain, which can be caused by any of the following: arthritis, dislocation, injury, jaw and/or tooth misalignment, and stress/teeth grinding. The prevalence of TMJ joint disorders in the rest of the world is estimated to be similar to that in the US.